Mechanism of Disease / Mechanism of Action
Mechanism of Disease
Apoptosis – form of programmed cell death initiated through pathways that are intrinsic, e.g., cell stress, or extrinsic, e.g., signals from other cells
VDAC1 – protein that regulates day-to-day mitochondrial function. During apoptosis – over-expression of VDAC1 leads to development of a “super channel” (oligomerization) that mediates the release of apoptotic proteins (cytochrome c) from the mitochondria and allows apoptosis.
Mechanism of Action
VBIT-4 and VBIT-12 inhibit VDAC1 oligomerization